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相关概念视频

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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相关实验视频

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Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris
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肌肉骨疾病中的微塑料:一个新兴的威胁

Madhan Jeyaraman1, Naveen Jeyaraman1, Arulkumar Nallakumarasamy2

  • 1Department of Orthopaedics, ACS Medical College, and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu 600077 India.

Indian journal of orthopaedics
|December 15, 2025
PubMed
概括

微塑料 (MP) 通过引起炎症和细胞损伤,损害肌肉骨系统. 研究表明潜在的长期骨和肌肉退化,强调需要对这些塑料污染物进行人体研究.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.退化退化的情况.微塑料是一种微塑料.骨质细胞生成 (Osteoclastogenesis) 是一个过程.

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Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
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Last Updated: Jan 8, 2026

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科学领域:

  • 环境健康 环境健康
  • 毒理学 毒理学 毒理学
  • 肌肉骨科学 肌肉骨科学

背景情况:

  • 微塑料 (MP) 是普遍存在的环境污染物,具有已知的系统毒性.
  • MPs对肌肉骨系统的影响仍未得到充分研究.
  • 鉴于人类潜在的广泛暴露,了解这些影响至关重要.

研究的目的:

  • 审查和综合当前关于微塑料和纳米塑料对肌肉骨系统影响的文献.
  • 确定毒性的关键机制和在临床前和临床环境中观察到的结果.
  • 突出知识差距和未来的研究方向.

主要方法:

  • 使用主要科学数据库 (PubMed,Scopus,Web of Science) 进行了叙事文献审查.
  • 包括2010年至2024年间发表的研究,重点关注微塑料,纳米塑料及其对骨,软骨和肌肉的影响.
  • 包括标准优先考虑原始实验研究,动物模型和可用的临床数据.

主要成果:

  • 微塑料通过摄入,吸入和皮肤吸收进入人体,影响肌肉骨组织.
  • 观察到的效应包括氧化应激,炎症,亡,骨质母细胞/冠状细胞功能受损,骨质母细胞生成增加和肌肉再生受损.
  • 临床前模型显示慢性MP暴露后骨密度和肌肉缩减少;纳米塑料可能表现出不同的组织透和生物可用性.

结论:

  • 微塑料通过炎症,氧化损伤和细胞功能障碍对肌肉骨健康产生不利影响.
  • 目前的证据,主要来自临床前研究,表明长期骨和肌肉退化的潜力.
  • 迫切需要进一步的临床研究来证实这些影响在人类群体.