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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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广场细胞分辨率视网膜成像使用可变形镜式无传感器自适应光学时间域全场OCT.

Yao Cai^1,2, Olivier Martinache¹, Maxime Bertrand³

¹Institut Langevin, ESPCI Paris, CNRS, PSL University, Paris, France.

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|December 15, 2025

概括

这项研究引入了一种用于视网膜成像的新适应光学系统,在更广泛的视野中实现细胞分辨率. 简化方法提高了成像质量,并有助于在临床上采用详细的眼科检查.

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科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
在光学成像系统中,光学成像

背景情况:

适应光学 (AO) 提供细胞分辨率视网膜成像,但受到狭窄视野 (FOV) 的限制.
由于FOV限制和复杂性,当前的AO系统在临床采用方面面临挑战.

研究的目的:

开发和验证基于可变形镜 (DM) 的无传感器 AO 时域全场 OCT (FFOCT) 系统.
为了克服传统的AO眼镜镜的FOV限制.
为了使广场,细胞分辨率视网膜成像用于临床应用.

主要方法:

实现了无传感器的AO系统,使用与全场OCT (FFOCT) 集成的可变形镜 (DM).
在空间不连贯的照明下,利用FFOCT对眼睛偏差的强度.
为了纠正偏差,利用了3-5种泽尼克模式 (失焦,纹,昏迷) 的校正.

主要成果:

在信号与噪声比 (SNR) 和细视网膜结构的分辨率上显著提高.
实现了靠谱的可靠可视化圆光受体在中心 (0.3°) 附近.
启用了视网膜内部特征的深度分辨率成像,在500Hz的5°x5°FOV中进行.

结论:

开发的AO-FFOCT系统简化了AO的实施,同时实现了广场蜂分辨率.
这种方法解决了当前AO眼镜的关键局限性.
为更广泛的临床部署高分辨率视网膜成像提供了一个有希望的途径.