细丝形态的宏观进化在酵母子族的Saccharomycotina
Christina M Chavez1,2, Marie-Claire Harrison1,2, Thodoris Danis1,2
1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
bioRxiv : the preprint server for biology
|December 15, 2025
概括
大多数Saccharomycotina酵母可以形成丝,真和伪多次演变. 基因组和新陈代谢特征预测了丝状结构,为酵母菌的多样性提供了洞察力.
科学领域:
- 菌类学 菌类学是指菌类学.
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 萨卡罗米科蒂纳酵母表现出多样化的无性生长,包括单细胞芽和丝状的形式,如伪和真.
- 了解纤维化的进化和驱动因素是理解酵母多样性和生活方式的关键.
研究的目的:
- 为了研究整个Saccharomycotina的丝状结构的变异和进化历史.
- 为了确定基因组,代谢和环境因素如何预测不同的丝类型.
主要方法:
- 综合了来自1,154个Saccharomycotina菌株 (1,051种) 的表型,基因组,代谢和隔离环境数据.
- 利用祖先状态重建推断线条的进化模式.
- 应用机器学习模型,以基于基因组和代谢特征来预测细丝形态.
主要成果:
- 63.37%的菌株表现出丝状,其中6.56%形成真,42.40%伪,14.39%两者兼有.
- 丝状和真正的形形成与酵母菌的基因相比,与伪形的相关性更强.
- 祖先状态的重建表明了多个独立的丝状的进化,其中Saccharomycotina的祖先可能产生了 pseudohyphae.
结论:
- 形成真和/或伪的能力在Saccharomycotina中多次演变.
- 机器学习模型在预测光纤形态方面达到约70%的准确性.
- 连接进化,基因组,代谢和生态数据可以增强对Saccharomycotina多样性的理解.
相关概念视频
01:28Fungal Phylum Ascomycota
971
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
971
01:27Diversity of Protists IV
709
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
709
01:29Overview of Fungi
1.5K
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
1.5K
01:28Fungal Phylum Microsporidia
382
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
382
01:19Septins
2.2K
Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
2.2K
01:28Yeast Signaling
17.1K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.1K