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Updated: Jan 8, 2026

A High-throughput Cre-Lox Activated Viral Membrane Fusion Assay to Identify Inhibitors of HIV-1 Viral Membrane Fusion
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内体PIKfyve抑制如何防止病毒膜融合和进入病毒

Nicholas Chow1, Gustavo Scanavachi1,2,3, Anand Saminathan1,2

  • 1Program in Cellular and Molecular Medicine, Boston Children's Hospital, 200 Longwood Ave, Boston, MA 02115, USA.

bioRxiv : the preprint server for biology
|December 15, 2025
PubMed
概括

抑制PIKfyve酶会使内分体膨胀,阻断包裹病毒的进入和基因组的释放. 这种内分体胀会产生融合屏障,提供一种潜在的抗病毒策略来对抗使用这种入口途径的病毒.

关键词:
细胞内体融合 细胞内体融合格子光片显微镜 格子光片显微镜膜张力 张力 膜张力在 PIKfyve 抑制抑制中.病毒入口病毒入口

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