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相关概念视频

Frequency-dependent Selection01:21

Frequency-dependent Selection

23.0K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.0K
DNA Bacteriophages01:26

DNA Bacteriophages

744
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
744
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

1.2K
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
1.2K
Transduction01:16

Transduction

1.1K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.1K
Types of Selection01:46

Types of Selection

43.7K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
43.7K
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

77.3K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
77.3K

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相关实验视频

Updated: Jan 8, 2026

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems
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Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems

Published on: October 14, 2025

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空间约束驱动负频率依赖的菌体选择,菌体武器化.

Yixuan Peng, Jacob D Holt, Triana N Dalia

    bioRxiv : the preprint server for biology
    |December 15, 2025
    PubMed
    概括

    Lysogenized Vibrio cholerae最初会杀死生物膜中的非lysogens. 然而,生物膜的约束限制了菌体的传播,导致 lysogens 在它们变得普遍时被超越竞争,证明了负频率依赖的选择.

    科学领域:

    • 微生物学 微生物学
    • 生态生态学 生态生态学
    • 遗传学 遗传学 是一个

    背景情况:

    • 细菌在不同的环境中形成生物膜,遇到菌体.
    • 在细胞分辨率下研究生物膜中的菌体-宿主动态是具有挑战性的.
    • 在海洋环境中的Vibrio cholerae与生物膜内的菌体相互作用.

    研究的目的:

    • 在生物膜中研究 lysogenized 和非lysogenized Vibrio cholerae 的种群动态.
    • 了解菌体与宿主相互作用如何影响模拟海洋环境中的细菌健康状况.
    • 确定限制生物膜中 lysogens 的竞争取代的因素.

    主要方法:

    • 在流动的海水中的基颗粒上培养Vibrio cholerae生物膜.
    • 利用菌体K139及其衍生物具有不同的传染性.
    • 使用建模方法和成像实验.
    • 分析 lysogenized 和非 lysogenized 细菌的种群动态和空间分布.

    主要成果:

    • Lysogenized V. cholerae最初通过菌体释放来取代非lysogenized 细胞.
    • 生物膜中的空间限制和超级感染排除限制了菌体的传播.

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  • 由于菌体效率降低,当它们成为大多数人群时,素被淘汰.
  • 在现实条件下,负频率依赖选择对溶解细胞起作用.
  • 结论:

    • 生物膜架构和超级感染免疫力限制了菌体的有效性,限制了素的优势.
    • 菌体诱导的杀死和宿主种群密度之间的平衡塑造了细菌社区结构.
    • 温和菌体可以改变生物膜内的宿主健康状况,但这种效应依赖于密度.