呼吸系统微生物群与宿主相互作用对肺癌发生,免疫力和免疫疗法
Peng Wang1,2, Cuihong Ge1,2, Xinru Jing3
1Postgraduate Cultivation Base of Guangzhou University of Chinese Medicine, Panyu Central Hospital, Guangzhou, Guangdong, China.
Frontiers in immunology
|December 15, 2025
概括
呼吸道微生物群影响肺癌的发展和治疗反应. 了解它的作用为肺癌管理提供了新的治疗点和生物标志物.
科学领域:
- 肺病学和瘤学 在
- 微生物组研究 微生物组研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 呼吸道微生物组是肺癌微环境的关键因素,影响瘤发生,免疫平衡和治疗结果.
- 目前的肺癌免疫疗法面临着诸如多样化的反应,免疫副作用和缺乏预测生物标志物的挑战.
研究的目的:
- 分析呼吸道微生物群在肺癌发病过程中的作用及其对免疫环境的影响.
- 探索呼吸系统失调和肺癌特征之间的关联,包括分期,亚型和预后.
- 调查微生物组向策略的潜力,以改善肺癌免疫疗法.
主要方法:
- 对肺癌中呼吸道微生物组变化 (失生症) 的文献进行系统审查.
- 分析微生物特征之间的关联,肺癌分期,组织学和预后.
- 阐明了将微生物变化与瘤进展联系起来的代谢-表观遗传-免疫通路.
- 微生物组形状与免疫检查点抑制剂有效性和毒性的相关性.
- 检查抗生素对免疫治疗结果的影响.
主要成果:
- 呼吸系统疾病,以减少α多样性和丰富的链球菌和Veillonella的特征,与肺癌有关.
- 微生物变化通过代谢,表观遗传和免疫路径影响瘤的进展.
- 微生物组的特征与免疫检查点抑制剂的有效性和毒性相关,而抗生素暴露可以悖论地影响免疫疗法.
结论:
- 呼吸道微生物组在肺癌中扮演着双重角色,既是生物标志物,也是治疗点.
- 益生菌和工程细菌等新兴策略在调节抗瘤免疫力方面表现有前途.
- 进一步的研究对于将这些发现转化为肺癌管理的临床应用至关重要.
相关概念视频
Other Pulmonary Disorders
1.5K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.5K
COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Factors Affecting Pulmonary Ventilation
2.8K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.8K
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K


