细胞癌与静脉瘤血栓的术前分子疗法:系统性审查和元分析
Kewei Chen1, Lin Zhuo2, Zhuo Liu1
1Department of Urology, Peking University Third Hospital, Beijing, China.
Frontiers in immunology
|December 15, 2025
概括
手术前分子疗法 (PMT) 在细胞癌 (RCC) 患者中有效减少瘤血栓 (TT),简化了手术. 与PMT相关的不良事件通常是可以管理的.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医学治疗学 医学治疗学
背景情况:
- 与瘤血栓 (TT) 结合的细胞癌 (RCC) 提出了复杂的治疗挑战.
- 术前分子疗法 (PMT),包括氨酸激酶抑制剂 (TKI) 和免疫检查点抑制剂 (ICI),正在越来越多地探索TT的RCC.
- 在这个特定的患者群体中,PMT的结果和不良事件 (AE) 需要彻底评估.
研究的目的:
- 评估手术前分子治疗 (PMT) 对瘤血栓 (TT) 水平和瘤细胞癌 (RCC) 患者身高的影响.
- 评估与PT相关的治疗相关不良事件 (AEs) 的发生率和类型,这些不良事件与PTT相关,这些不良事件发生在患有TT的RCC患者中.
- 确定PMT在简化RCC与TT的手术过程中的潜力,特别是对于更高的梅奥等级.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane Library,Web of Science) 进行了系统的文献搜索,截至2023年6月.
- 包括调查PMT对有静脉TT的RCC患者的影响的研究,无论后续手术如何.
- 提取和分析了关于TT水平变化和与治疗相关的不良事件的数据.
主要成果:
- 总共有184名患者被纳入分析.
- 在30.7%的患者中,PMT导致TT水平下降,在117名患者中观察到平均减少15.2mm.
- 最常见的不良事件是高血压 (49.9%),手脚综合征 (25.5%),疲劳 (25.3%) 和腹 (20.2%).
结论:
- 手术前分子疗法 (PMT) 在细胞癌 (RCC) 患者的瘤血栓 (TT) 水平降低方面表现出有效性.
- PMT可能会简化手术干预,特别是对于患有更高度瘤血栓 (Mayo级3/4级) 的患者.
- 与PMT相关的不良事件通常是可以容忍和可管理的.
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