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Updated: Jan 8, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

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MCC950通过抑制NLRP3炎症体活动和下调调节Interleukin-23/Interleukin-17轴表达来缓解实验性自身免疫神经炎症

Yi Li1, Xiaocong Li1, Tao Gu2

  • 1Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, People's Republic of China.

Journal of inflammation research
|December 15, 2025
PubMed
概括

在NLRP3炎症酶驱动吉兰-巴雷综合征 (GBS) 通过上调IL-23/IL-17轴. 使用MCC950抑制这种途径显示了GBS治疗的治疗潜力.

关键词:
在MCC95050中,我们可以使用MCC950在NLRP3炎症酶组中,实验性的自身免疫性神经炎介质蛋白-23/介质蛋白-17轴

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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