基于venetoclax和homoharringtonine的疗法在耐药/复发的早期T细胞前体急性淋巴细胞白血病中表现出惊人的反应
Xiang Zhang1, Hongsheng Zhou2, Liping Mao1
1Department of Hematology The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang PR China.
MedComm
|December 15, 2025
概括
结合venetoclax和homoharringtonine的V-HAG疗法在治疗不耐药/复发的早期T细胞前体急性淋巴细胞白血病 (ETP-ALL) 中具有很高的疗效. 这种有前途的疗法在所有患者中实现了完全缓解,改善了生存率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 早期T细胞前体急性淋巴细胞白血病 (ETP-ALL) 是T细胞急性淋巴细胞白血病 (T-ALL) 的攻击性亚型.
- 耐药性或复发性ETP-ALL的预后不佳,再诱导治疗的成功率有限 (36%-46%完全缓解).
- 之前的研究表明,在ETP-ALL模型中,venetoclax (VEN) 和同素 (HHT) 之间存在协同效应.
研究的目的:
- 调查V-HAG疗法 (VEN,HHT,cytarabine,G-CSF) 对耐火性/复发性ETP-ALL的疗效和安全性.
- 在2期临床试验中评估V-HAG疗法作为再诱导疗法.
主要方法:
- 有望的,多中心的,单臂的,开放的,第二阶段的临床试验.
- 18名耐火性/复发性ETP-ALL患者接受了V-HAG疗法.
- 评估完全缓解 (CR),不完全血液恢复 (CRi) 的CR,复发率,死亡率,存活率和不良事件.
主要成果:
- 100%的患者在一轮V-HAG治疗后获得了CR或CRi.
- 一年总生存率为76.7%,无复发生存率为55.7%.
- 常见的3-4级不良事件包括中性质衰竭 (100%),血小板衰竭 (100%) 和贫血 (88.9%).
结论:
- V-HAG疗法在治疗耐火性/复发性ETP-ALL方面表现出极高的疗效.
- 这种基于VEN和HHT的疗法耐受性良好,并提供了一种有前途的策略来改善患者的治疗结果.
- V-HAG疗法在治疗这种侵袭性白血病亚型方面取得了重大进展.
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