Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Thermosensation01:43

Thermosensation

33.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.6K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

3.9K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
3.9K
GPCR Desensitization01:12

GPCR Desensitization

7.9K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
7.9K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.5K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.5K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

3.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Can habitat modification in the native range promote invasion?

Trends in ecology & evolution·2026
Same author

A Chromosome-Level Assembly of the Pine Processionary Moth (Thaumetopoea pityocampa) genome.

The Journal of heredity·2026
Same author

Dosimetric characteristics of the new Papillon+® system for breast intraoperative radiotherapy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells.

Cell biology and toxicology·2026
Same author

Second Ipsilateral Breast Cancer Event: True Recurrence, New Primary, or True Recurrence Like? : Breast Cancer Local Recurrence.

Annals of surgical oncology·2026
Same author

Fecal incontinence after prostate cancer irradiation: a systematic literature review.

Prostate cancer and prostatic diseases·2026
Same journal

Experimental and Mechanistic Validation of PARP1pred for Identifying Potent Leads.

Computational and structural biotechnology journal·2026
Same journal

DepMicroDiff: Diffusion-Based Dependency-Aware Multimodal Imputation for Microbiome Data.

Computational and structural biotechnology journal·2026
Same journal

Simulating Multicolor Super-Resolution Imaging Using an RGB Camera.

Computational and structural biotechnology journal·2026
Same journal

MetaphorPrompt2-A Structure and Function-Focused Approach for Extracting Causal Events from Biological Text.

Computational and structural biotechnology journal·2026
Same journal

Microbiome-Metabolome Crosstalk in HPV Pathogenesis: From Ecosystem Dynamics to Translational Biomarkers.

Computational and structural biotechnology journal·2026
Same journal

Minimum-Cost Synthetic Genome Planning: An Algorithmic Framework.

Computational and structural biotechnology journal·2026
查看所有相关文章

相关实验视频

Updated: Jan 8, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.5K

解锁TRPM7交互:一个数据库驱动的任务.

Nicolas Jonckheere1, Lise Rodat-Despoix2, Isabelle Dhennin-Duthille2

  • 1Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille 59000, France.

Computational and structural biotechnology journal
|December 15, 2025
PubMed
概括
此摘要是机器生成的。

短暂受体潜在阴离子通道亚家族M成员7 (TRPM7) 是一种涉及恶性瘤的双重功能蛋白质. 这项研究确定了TRPM7相互作用体,揭示了肠直肠癌和胰腺癌等消化系统癌症的潜在治疗标.

关键词:
在BioGRID数据库中.这是GSEAGSEA.蛋白互动组是一种蛋白互动组.TRPM7 TRPM7 是一个很好的方法.

更多相关视频

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.6K
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.4K

相关实验视频

Last Updated: Jan 8, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.5K
Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.6K
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.4K

科学领域:

  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学
  • 在瘤学瘤学.

背景情况:

  • 过渡受体潜在阴离子通道子家族M成员7 (TRPM7) 是一种具有通道和激酶功能的蛋白质.
  • TRPM7与包括癌症在内的各种疾病有关,使其成为潜在的治疗点.
  • 了解TRPM7的相互作用对于阐明疾病机制和开发新疗法至关重要.

研究的目的:

  • 为了识别和描述TRPM7.7的蛋白相互作用体.
  • 探索TRPM7在消化系统瘤的背景下的作用.
  • 为了发现精准医学的潜在治疗目标.

主要方法:

  • 已知TRPM7相互作用伙伴的文献综述.
  • 分析公开的蛋白质相互作用数据库 (例如,BioGRID).
  • 使用计算工具 (例如,ProteinPrompt) 建模蛋白相互作用.

主要成果:

  • 确定了19个感兴趣的基因作为潜在的TRPM7相互作用体.
  • 这些相互作用体与小GTPase通路有显著的关联.
  • 确定的途径与消化系统癌症有关,包括结直肠和胰腺癌.

结论:

  • 该研究提供了潜在的TRPM7交互器的扩展概述.
  • 需要在细胞模型中进一步验证以确认这些相互作用.
  • 这项研究为瘤细胞膜的分子机制提供了洞察力,为新的治疗策略铺平了道路.