在无症状患者服用Bacillus Calmette-Guérin之前,现在是放弃常规尿液分析的时间
Antti Nummi1, Pertti Nurminen2, Olli Kesti2
1Department of Urology Helsinki University and Helsinki University Hospital Helsinki Finland.
BJUI compass
|December 15, 2025
概括
无症状细菌性尿病 (ABU) 不会增加在Bacillus Calmette-Guérin (BCG) 灌注后入院的风险. 在BCG治疗前对非肌肉侵入性膀癌患者不需要进行ABU的例行查.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- Calmette-Guérin (BCG) 是一种用于治疗非肌肉侵入性膀癌 (NMIBC) 的标准免疫疗法.
- 无症状细菌性尿病 (ABU) 是在尿液中存在细菌而没有症状.
- ABU复杂化BCG灌注的潜在风险是一个临床问题.
研究的目的:
- 调查ABU是否增加了BCG灌注后需要住院治疗的感染并发症的风险.
- 在无症状患者中评估BCG前查细菌尿的必要性.
主要方法:
- 在2009-2018年期间接受BCG治疗NMIBC的患者的回顾性分析.
- 尿液培养是在每次BCG灌注前1-7天获得的.
- 记录了在BCG治疗2周内因尿路感染或BCG相关不良反应入院的病例.
主要成果:
- 分析了802名患者和12968个BCG灌注.
- 在19%的灌之前,ABU已经存在.
- 患有ABU和没有ABU的患者之间的住院率相似 (0.3%对0.4%,P=0.9).
结论:
- 在ABU患者中,BCG灌注是安全的.
- 在BCG免疫疗法之前对无症状细菌尿的常规查并未得到这些发现的支持.
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