感染Pentatrichomonas hominis诱导了免疫能力强小鼠的慢性肠道炎症

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Yao Rong¹, Yidan Cheng¹, Hongbo Zhang¹

¹State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China, jlu.edu.cn.

Transboundary and emerging diseases

|December 15, 2025

概括

在小鼠中,Pentatrichomonas hominis (P. hominis) 导致慢性肠道炎症和损伤. 这种原生动物可能是一个被忽视的动物性传染病原体,影响肠道健康和微生物群组成.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
病原体研究病原体研究

背景情况:

人类的Pentatrichomonas (P. hominis) 经常被认为是一个共生的或机会性的肠道居民.
新出现的证据表明P. hominis可能是肠道疾病的唯一病原体,表明潜在的动物传播.

研究的目的:

在小鼠模型中系统评估P. hominis的致病性.
调查P. hominis感染对大肠和肠道微生物群的影响.

主要方法:

在健康的免疫能力强的BALB/c小鼠中感染了P. hominis.
肠道组织的组织病理学分析.
对杯状细胞标记物的评估 (PAS,MUC2).
测量促炎性细胞因子.
对肠道微生物群组成的分析.

主要成果:

P. hominis 感染引发了持续的大肠损伤,包括炎症,亡和粘膜脱落.
杯细胞功能被破坏,改变了PAS染色和MUC2的产生.
在肠道洗液和血清中,促炎性细胞因子增加.
肠道微生物群的组成发生了变化,增加了Desulfovibrio的丰富性,多样性和丰富性,并减少了像Akkermansia这样的有益细菌.

结论:

P. hominis 作为一种动物性病原体,诱导慢性肠道炎症.
这项研究提供了P. hominis作为肠道病理病因的证据.
对P. hominis感染的临床意义需要进一步关注.

关键词:

五太族人 (Pentatrichomonas hominis) 是人类的一种类型.我们的肠道微生物群.这是一种炎症炎症炎症炎症.病原体是一种病原体.病原性病原性病原性

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