肝细胞癌的切除后复发:分子病原和有针对性的治疗创新
Jiamin Chen1,2, Jinshu Pang1,2, Dongyue Wen1
1Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi Zhuang Autonomous Region, China.
American journal of cancer research
|December 15, 2025
概括
热性切除后肝细胞癌 (HCC) 复发是常见的. 本综述详细介绍了分子机制和精密疗法,为更好的个性化治疗策略提供了见解.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 在瘤学瘤学.
- 癌症复发的分子机制
背景情况:
- 肝细胞癌 (HCC) 是一种流行癌症,预后不佳.
- 热废除疗法,如射频废除 (RFA) 和微波废除 (MWA) 是早期HCC的主要治疗方法.
- 高复发率限制了对HCC的热废除的有效性.
研究的目的:
- 系统地审查驱动HCC复发后热废除的分子机制.
- 为了对抗这些复发机制而开发的精确干预策略进行分类.
- 为个性化治疗和HCC复发的未来研究提供基础.
主要方法:
- 2017年至2025年研究的系统文献综述.
- 对HCC复发的多维分子机制的分类.
- 针对HCC复发的精确干预策略的分类.
主要成果:
- 确定了HCC复发的关键机制:免疫微环境重塑,细胞死亡逃避,代谢重编程,表观遗传异常,干性,EMT,血管生成和非编码RNA.
- 详细介绍了各种精确干预措施,包括免疫疗法,代谢调节,表观遗传疗法,干细胞抑制,EMT逆转和抗血管生成.
- 突出了综合治疗的多目标组合策略.
结论:
- 了解各种分子机制对于解决HCC复发至关重要.
- 精确干预策略提供有针对性的方法来克服治疗局限性.
- 本综述为为HCC患者制定个性化,全面的治疗计划提供了框架.
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