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常见的生物标志物和炎症性肠病和乳腺癌的发病:门德尔随机化和多组学研究

Daqing Zhang¹, Yongjun Guan¹, Haitao Tang²

¹Department of General Surgery, Beijing Friendship Hospital, Capital Medical University,State Key Lab of Digestive Health,National Clinical Research Center for Digestive Diseases, Beijing, People's Republic of China.

Breast cancer (Dove Medical Press)

|December 15, 2025

概括

炎症性肠病 (IBD) 增加了乳腺癌的风险. 该研究确定THBS3作为一个共享的生物标志物,可能会推动癌症的进展,并为改善患者的治疗结果提供治疗目标.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
免疫学免疫学免疫学

背景情况:

炎症性肠病 (IBD) 和乳腺癌是全球主要的健康问题.
流行病学研究表明存在联系,但因果关系和机制尚不清楚.
这项研究调查了IBD和乳腺癌之间的因果关系和共同的分子途径.

研究的目的:

为了确定IBD是否因果影响乳腺癌风险.
为了确定IBD和乳腺癌之间共享的遗传生物标志物.
探索IBD与乳腺癌相关性背后的分子机制.

主要方法:

使用GWAS数据的双样本孟德尔随机化 (MR).
在公共数据库中识别和验证共享基因 (GEO,TCGA).
功能性研究包括免疫组织化学,RT-PCR,免疫透,药物敏感性,分子对接,ceRNA网络和通路分析 (GSEA,GSVA).

主要成果:

核磁共振分析证实IBD是乳腺癌的重要风险因素.
确定THBS3是一种常见过度表达的基因,与预后不佳和耐药性有关 (Dinaciclib,Daporinad,Rapamycin).
THBS3与miR-423-5p相互作用,并参与ECM受体相互作用和蛋白质酶体通路.

结论:

提供IBD作为乳腺癌风险因素的遗传证据.
强调THBS3作为乳腺癌的潜在生物标志物和治疗点,特别是在IBD患者中.
表明THBS3在免疫调节,ECM重塑和耐药性方面的作用.

关键词:

克罗恩氏病是什么克罗恩氏病是什么 IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD 门德尔的随机化乳腺癌乳腺癌乳腺癌性结肠炎是一种

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