案例报告:缺乏是因恩福图马布维多丁诱导皮肤不良事件的可修改风险因素
Aya Nishizawa1, Masaya Itoh2, Midori Inoue1
1Department of Dermatology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Frontiers in oncology
|December 15, 2025
概括
缺乏可能会使皮肤副作用如皮疹恶化,在治疗因尿路癌而使用恩福图马布维多丁 (EV) 的患者中. 补充迅速改善了严重的皮疹,这表明它可以帮助治疗的连续性.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 营养科学 营养科学
背景情况:
- 恩福图马布维多丁 (EV) 对于晚期泌尿腺癌是有效的.
- 皮肤不良事件 (CAE),特别是对称的与药物相关的三角形间和曲式外 (SDRIFE) 类似的喷发,是治疗的重大障碍.
- 缺乏可以引起类似的皮肤病,暗示与EV引起的皮肤毒性有关.
研究的目的:
- 调查缺乏症和EV诱导的CAE之间的关联.
- 评估补充剂在管理这些不良事件中的有效性.
主要方法:
- 用EV治疗的10名晚期泌尿腺癌患者的回顾性分析.
- 在CAE或dysgeusia开始时测量血清水平.
- 评估皮疹严重程度和对补充剂的反应.
主要成果:
- 所有患者的血清含量都低于正常水平.
- 在6名患者中观察到类似SDRIFE的皮疹,与没有皮疹患者相比,水平显著降低.
- 补充剂导致三名患者的SDRIFE类皮疹迅速改善,即使是那些对皮质类固醇耐药的患者.
结论:
- 缺乏可能导致EV诱导的SDRIFE类喷发.
- 补充剂显示出作为有效的辅助疗法的承诺,用于管理这些皮肤毒性.
- 监测状况和补充剂可以改善接受EV的晚期泌尿腺癌患者的治疗坚持和连续性.
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