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肠道微生物组的改变及其对卵巢癌的临床和生物学影响:系统性审查

Beibei Zhang¹, Nur Fatin Nabilah Mohd Sahardi², Kah Teik Chew¹

¹Department of Obstetrics and Gynecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Frontiers in oncology

|December 15, 2025

概括

肠道微生物组在卵巢癌患者中发生变化,影响诊断和治疗反应. 了解这些变化对于开发基于微生物组的新疗法至关重要.

科学领域:

微生物组研究的研究.
卵巢癌的生物学
治疗策略治疗策略

背景情况:

人们越来越认识到肠道微生物组 (GM) 在卵巢癌 (OC) 进展中的作用.
关于OC患者的转基因成分和多样性的研究有限.
转基因改变可能为OC提供新的干预策略.

研究的目的:

系统地审查有关肠道微生物组组成和卵巢癌多样性的现有证据.
分析转基因与OC诊断,术后变化和治疗反应的关联.
识别潜在的基于微生物组的生物标志物和治疗点.

主要方法:

在PubMed和Web of Science的系统文献搜索到2025年10月.
包括涉及人类受试者的原始研究文章.
提取和分析OC患者的转基因变异,术后变化以及对化疗或PARP抑制剂 (PARPi) 治疗的反应数据.

主要成果:

在诊断时,OC患者表现出肠道失生症,蛋白质细菌增加,Firmicutes减少.
特定的属,如 *Akkermansia*, *Bacteroides* 和 *Prevotella* 显示变化的水平.
手术后和化疗期间,微生物组的组成发生了显著的变化,已经确定了治疗耐药性的潜在生物标志物.

结论:

在卵巢癌患者中,肠道微生物组的组成在疾病阶段和治疗过程中是动态的.
需要进一步的研究来探索OC的微生物向治疗策略.
这项研究强调了肠道微生物组在卵巢癌诊断和治疗中的潜力.

关键词:

癌症生物标志物癌症生物标志物这种疾病叫做dysbiosis.我们的肠道微生物组.基于微生物组的疗法卵巢癌是发生在卵巢的癌症.

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