在低度质瘤手术中患者的选择和结果
Margret Jensdottir1,2, Ole Solheim3,4, Alba Corell5,6
1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Frontiers in oncology
|December 15, 2025
概括
最大限度的安全切除是扩散性低度质瘤 (dLGG) 管理的关键. 这项研究发现,手术选择取决于患者的年龄和瘤特征,中位切除程度 (EOR) 为83%,与较差的结果无关.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 扩散性低度质瘤 (dLGG) 管理依赖于最大安全切除,但流行病学数据很少.
- 了解DLGG手术选择,技术和结果对于改善患者护理至关重要.
研究的目的:
- 探索基于人口的扩散性低度质瘤 (dLGG) 队列中的手术选择,技术和结果.
主要方法:
- 一个多中心病例系列的成年人与 supratentorial dLGG (世卫组织二级) 接受初级手术 (2012-2017).
- 评估30天的并发症和3个月的神经结果.
- 在手术前和手术后MRI的中央审查.
主要成果:
- 在517名患者中,77%接受了切除,切除程度 (EOR) 的中位数为83%.
- 只有活检的患者年龄较大,瘤较大,位置更为明确.
- 在41.5%的患者中出现了新的/恶化的神经缺陷,在3个月后持续在4.8%的患者中. 21,4%的患者出现并发症.
结论:
- 对于dLGG的外科选择受到年龄,瘤大小和位置的影响.
- 获得了83%的中位数EOR,年龄和瘤生物学预测了EOR,而不是更高的风险或更糟糕的结果.
- 手术方法的变化凸显了DLGG管理中的持续争议.
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