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有机-无机的异构结构使受感染的伤口愈合

Miaomiao He¹, Ce Zhu¹, Chuang Liu¹

¹College of Biomedical Engineering, Department of Orthopedic Research Institute and Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610065, China. ywz@scu.edu.cn.

Journal of materials chemistry. B

|December 15, 2025

概括

这项研究引入了一种新的Ag2S/IEICO-4F有机-无机异构结构,用于对抗致病性感染. 这种材料在近红外光下有效地产生反应性氧物种,显示出强大的抗菌和伤口愈合能力.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
摄影化学的使用.

背景情况:

致病性感染对人类健康构成重大威胁.
异构结构为对抗病原体提供了一种有效的策略.
有机-无机的异构结构代表了材料设计的先进前沿.

研究的目的:

开发和描述一种新的Ag2S/IEICO-4F有机-无机异构结构.
评估异构结构在近红外 (NIR) 辐射下产生反应性氧物种 (ROS) 的有效性.
在体内评估Ag2S/IEICO-4F异构的抗菌和伤口再生能力.

主要方法:

Ag2S/IEICO-4F异构结构的制造.
在NIR照射下对ROS生成 (单氧基,超氧基,基) 的评估.
在感染金黄色葡萄球菌的老鼠皮肤缺陷模型上的体内测试.

主要成果:

由于电子孔分离的改进,Ag2S/IEICO-4F异构表现出与单个组件相比增强的ROS生成.
显示出对黄金葡萄球菌具有显著的抗菌活性.
在老鼠受感染的皮肤缺陷中促进伤口再生.

结论:

Ag2S/IEICO-4F异构结构是光诱导抗菌应用的一个有前途的平台.
这项工作突出了有机-无机异构结构在应对传染病方面的潜力.
开发的材料设计策略为未来抗菌疗法的进步提供了一条途径.

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