探索血清25-基维生素D水平与儿科人口过敏性鼻炎严重程度之间的关系
Cankat Genis1, Fatma Nur Kuzucu1, Ahmet Selmanoglu1
1Department of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, Ankara, Türkiye.
Postgraduate medicine
|December 15, 2025
概括
低维生素D (血清25-氧维生素D3) 水平与儿童过敏性鼻炎 (AR) 严重程度的增加有关. 补充改善了AR症状,表明维生素D可以改善AR症状.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 血清25-基维生素D3 (s25-OHD3) 可能会影响过敏疾病中的免疫反应.
- s25-OHD3水平,过敏性鼻炎 (AR) 严重程度和过敏原敏感性之间的确切关系需要进一步阐明.
研究的目的:
- 调查s25-OHD3水平与儿童AR严重程度之间的关联.
- 探索过敏原敏感化在这种关系中的作用.
- 评估儿科AR中对维生素D补充剂的临床反应.
主要方法:
- 对343名患有AR的儿童 (2-18岁) 进行了回顾性研究.
- 评估s25-OHD3水平,过敏原敏感性 (皮肤刺伤测试/血清特异性IgE) 和临床特征.
- 根据ARIA指南对AR的严重程度进行分类;在12周维生素D补充后重新评估.
主要成果:
- 较低的s25-OHD3水平与增加的AR严重程度有显著的相关性 (p < 0.001).
- 维生素D缺乏与过敏性结膜炎,喘,亚托皮炎和猫毛敏感性有关.
- 严重AR的独立风险因素包括低s25-OHD3,过敏结膜炎,花粉敏感化和多敏感化.
- 维生素D补充剂导致AR严重程度显著降低 (p < 0.001).
结论:
- 维生素D缺乏是导致儿科过敏性鼻炎严重程度的一个重要因素.
- 监测s25-OHD3水平对于管理儿科AR至关重要.
- 涉及维生素D补充的有针对性的治疗策略可以改善AR结果.
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