静脉注射infliximab的时间影响着炎症性肠病的结果
Zoe Post1, Agnieszka Maniak1, Anthony DeMeo2
1Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, Illinois, USA.
在炎症性肠病 (IBD) 峰值之前,当天早些时候服用infliximab可能会改善患者的结果. 与较晚的剂量相比,早期的剂量显示出更好的CRP反应和有利的白蛋白变化.
科学领域:
- 胃肠病学 胃肠病学
- 时间生物学 时间生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD) 涉及过度的炎症反应.
- 这些反应表现出昼夜节律性,在晚上达到峰值.
- 目前的治疗时间可能无法优化治疗疗效.
研究的目的:
- 调查一天早些时候静脉注射因弗利克西马布是否会提高IBD患者的治疗效果.
- 根据Infliximab的使用时间,比较临床和生化结果.
主要方法:
- 追溯性概念验证研究涉及113名IBD成年患者.
- 接受住院治疗的患者被分为"早期" (12:00-18:00小时) 和"晚期" (18:00-00:00小时) 给药时间.
- 评估的结果包括住院治疗,手术,C反应蛋白 (CRP) 和白蛋白水平.
主要成果:
- "早期"组与"晚期"组相比,显示出更高的72小时CRP反应 (83%对71%) 和40天CRP显著改善 (p=0.0006).
- 7天后",早期"组的白蛋白水平有所改善 (+8%),而"晚期"组的白蛋白水平有所恶化 (-17%).
- 虽然边际",早期"组的30天手术和再入院率较低,尤其在女性中显著.
结论:
- 早期 (在18:00小时前) 给药似乎与改善IBD的炎症控制和临床结果有关.
- 这种时间可能会优化Infliximab的疗效,因为它会在夜间炎症峰值之前发生.
- 需要进一步的前性研究来证实这些发现.
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