选择性色素再吸收抑制剂对心脏病患者出血率的影响Mate 3 左心室辅助装置 患者不服用阿司匹林
Madeline Ganter1, MaryAnn Bowyer2, Emily Relic1
1UNC Medical Center, Chapel Hill, North Carolina, USA.
Artificial organs
|December 15, 2025
概括
选择性血红素再吸收抑制剂 (SSRI) 和血红素 - 上腺素再吸收抑制剂 (SNRI) 的使用并没有增加不服用阿司匹林的HeartMate 3 (HM3) 左心室辅助装置 (LVAD) 患者的重大出血风险. 需要进一步的研究来证实在更大的患者群体中这一发现.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 医疗器械 医疗器械
背景情况:
- 选择性血红素再吸收抑制剂 (SSRI) 和血红素 - 上腺素再吸收抑制剂 (SNRIs) 与治疗华法林和阿司匹林的左心室辅助器件 (LVAD) 患者的出血增加有关.
- 自2019年以来,机构已经改变了对HeartMate 3 (HM3) LVAD患者的阿司匹林处方.
研究的目的:
- 评估与SSRI/SNRI使用相关的严重出血风险,在没有服用阿司匹林的HM3 LVAD患者中.
- 在特定的LVAD人群中调查抗抑郁药物和出血事件之间的关联.
主要方法:
- 进行了一项单中心回顾性队列研究.
- 这项研究分析了101名HM3 LVAD患者的重大出血事件 (INTERMACS类型2,3a,3b,5).
- 使用多变量Cox比例危险回归,调整相关临床因素.
主要成果:
- 在101名患者中,60%接受了SSRI/SNRIs.
- 严重出血发生在SSRI/SNRI组的18%和非SSRI/SNRI组的15%.
- 多变量分析显示出出血风险没有显著差异 (HR1.04,p=0.43).
结论:
- 在不服用阿司匹林的HM3 LVAD患者中,SSRI/SNRI使用与大出血风险的增加没有显著关联.
- 需要进行更大规模的人口研究来验证这些发现.
- 这表明,当阿司匹林被遗漏时,这些抗抑郁药在这个特定的患者队列中具有潜在的安全性.
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