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肝移植后囊肌肉质量和密度的下降在移植前肌肉量和密度最高的患者中最大

Michael G Megaly¹, William C Miller^1,2, Jessica Thul³

¹Division of Solid Organ Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.

Clinical transplantation

|December 15, 2025

概括

肝移植 (LT) 可以导致肉症,肌肉质量和密度的损失. 初始肌肉质量较高的患者在移植后经历了最大的下降,这表明LT后肌肉变化的多因素影响.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
放射学放射学是一门学科.
老年病的医生老年病的医生

背景情况:

麻症是肝移植 (LT) 接受者的发病率和死亡率的重要预测因素.
肌面积 (PAI) 和平均霍恩斯菲尔德单位 (mHU) 是CT衍生的关键指标,用于评估肉症.
关于LT前后的psoas肌肉变化存在有限的数据.

研究的目的:

为了研究肝移植前后的psoas肌肉区域和密度的变化.
分析移植前肉症严重程度对移植后肌肉变化的影响.

主要方法:

对104名成年肝移植接受者的移植前和移植后CT扫描进行了回顾性分析.
肌肉质量和密度的Psoas面积指数 (PAI) 和平均Hounsfield单位 (mHU) 的量化.
通过移植前PAI四分位数对结果的分层.

主要成果:

在LT后的PAI (12%) 和mHU (7%) 总体下降.
在PAI (-15%) 和mHU (-15%) 中最显著的减少观察到的是基线肌肉质量和密度最高的患者.
在PAI和mHU变化之间没有发现相关性.

结论:

肝移植与肌肉质量和密度下降有关.
具有较高基线肌肉质量的患者在移植后经历了最严重的肌肉损失.
在LT后的肌肉变化受到多种因素的影响,需要进一步调查.

关键词:

肝移植肝移植肝移植营养营养营养营养胸肌肌面积指数:平均霍恩斯菲尔德单位,肉.

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