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第二代长效注射药与口服抗精神病药的产科结果
Farah Khorassani1, Gemma Espejo2, Kelly C Lee3,4
1Department of Clinical Pharmacy Practice, University of California, Irvine School of Pharmacy and Pharmaceutical Sciences, Irvine, California.
The Journal of clinical psychiatry
|December 15, 2025
概括
使用第二代长效注射抗精神病药物 (LAIA) 或口服抗精神病药物的孕妇有类似的产科结果,包括妊娠糖尿病和高血压疾病. 在两组之间,剖腹产率也相似.
科学领域:
- 产科和妇科 产科和妇科
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 第二代抗精神病药物用于管理孕妇的精神疾病.
- 长效注射抗精神病药 (LAIA) 为口服配方提供了替代的注射途径.
- 关于LAIA与口服第二代抗精神病药物的产科安全性的数据有限.
研究的目的:
- 为了比较暴露于第二代LAIAs和第二代口服抗精神病药物的孕妇患者的产科结果.
- 为了评估妊娠糖尿病,孕前,孕后和新高血压疾病的发病率.
- 在两个治疗组中评估剖腹产率.
主要方法:
- 使用TrinetX数据库对148个医疗保健机构进行了回顾性研究.
- 创建了两个队列:孕妇患者暴露于长期作用的阿里皮普拉,瑞斯佩里,帕利佩里或奥兰扎宾 (n=2,082) 和那些暴露于口服配方 (n=31,376) 的患者.
- 使用倾向性得分匹配,主要结果包括复合产科并发症和剖腹产率.
主要成果:
- 在倾向匹配后,每个队列中有2025名患者.
- 在LAIA和口服抗精神病药物组 (OR 0.95;95% CI,0.76-1.18;P=.61) 之间,在复合初级终点 (妊娠糖尿病,妊娠前,妊娠前,高血压障碍) 中没有发现显著差异.
- 剖腹产率在两组之间也是相似的.
结论:
- 第二代长效注射抗精神病药物 (LAIA) 和口服抗精神病药物在重大产科并发症方面表现出相似的安全性.
- 这些发现支持在临床上适用时在孕妇患者中使用LAIA,具有类似的妊娠糖尿病,高血压疾病和剖腹产风险.
- 进一步的研究可能会探索特定的LAIA代理物和长期新生儿结果.
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