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通过呼出的挥发性有机化合物对结肠直肠癌进行歧视

Yongyan Ji¹, Wenshan Wang¹, Shanshan Dong¹

¹Department of Environmental Science & Engineering, Fudan University, Shanghai, 200438, P.R. China.

QJM : monthly journal of the Association of Physicians

|December 15, 2025

概括

一种新的呼吸测试可以识别挥发性有机化合物 (VOC),以非侵入性检测结肠直肠癌 (CRC). 这种有前途的查工具显示出早期诊断的潜力,将CRC与其他胃肠道疾病区分开来.

科学领域:

生物标志物生物标志物
在瘤学瘤学.
呼吸系统医学呼吸系统医学

背景情况:

结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
早期检测对于改善CRC患者的治疗结果至关重要.
呼出的气息中的挥发性有机化合物 (VOC) 提供了一个非侵入性的查途径.

研究的目的:

为CRC检测开发和验证一个特定的呼吸VOC签名.
用呼吸分析来区分CRC与其他胃肠道疾病.
评估VOC和血清生物标志物的联合诊断性能.

主要方法:

招募了248名参与者,包括CRC患者,其他胃肠道疾病和健康对照.
对口服化合物,性行为和药物等混因素进行控制.
在独立的队列中为VOC面板开发和验证机器学习模型.

主要成果:

确定了一个VOC面板,将CRC与控制区分开来,AUC为0.834.
呼吸测试区分了CRC与性结肠炎 (AUC0.765) 和胰腺癌 (AUC0.739).
组合的VOC和血清生物标志物达到0.881.1的AUC.

结论:

在CRC患者中排出的明显的VOC显示出非侵入性查的潜力.
呼吸测试代表了早期CRC检测的强大方法.
与血清生物标志物的整合提高了诊断的准确性.

关键词:

生物标志物生物标志物呼吸测试是一种呼吸测试.结肠直肠癌是一种癌症.非侵入性查检查是非侵入性的.

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