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Updated: Jan 8, 2026

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors
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新的抗癌药物4-利基胺-5-碳酸盐向Hsp90的目标

Cinzia Bordoni1,2, Tia Z Elstow1, Andrea Brancale1,3

  • 1School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, UK.

Chemical biology & drug design
|December 15, 2025
PubMed
概括

研究人员开发了新的4-aryldihydropyrimidinone-5-carboxylate衍生物作为热冲击蛋白90 (Hsp90) 抑制剂用于癌症治疗. 化合物5d显示出强大的抗癌活性和Hsp90抑制,使其成为进一步药物开发的有希望的候选者.

关键词:
抑制 Hsp90 的发生.抗癌药物设计 抗癌药物设计乳腺癌 乳腺癌 乳腺癌多元组件比吉内利反应

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