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相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

20.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Genetic Lingo01:11

Genetic Lingo

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Overview
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Genomics02:02

Genomics

39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.5K
Design Example: Setting a Curve Using Design Data01:09

Design Example: Setting a Curve Using Design Data

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Designing and plotting a curve using field data requires precise calculations and execution. A horizontal curve with a radius of 200 meters and an intersection angle of 20 degrees is established using the method of perpendicular offsets from the long chord. The long chord, which spans between the curve's endpoints, is calculated to be 69.46 meters in length. To maintain accuracy in plotting, intervals of 3 meters are selected along the chord.The engineer determines the offset distances for each...
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相关实验视频

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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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设计空间和声明语法用于3D基因组数据可视化.

David Kouril, Trevor Manz, Sehi L'Yi

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    此摘要是机器生成的。

    这项研究阐明了如何可视化三维 (3D) 基因组结构和相关数据. 它引入了增强的可视化语法,以更好地表示空间基因组信息.

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    相关实验视频

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    科学领域:

    • 计算生物学 计算生物学
    • 基因组学可视化 基因组学可视化
    • 生物信息学是一种生物信息学.

    背景情况:

    • 计算方法产生三维 (3D) 基因组模型,以了解基因组的组织和功能.
    • 现有的可视化研究尚未明确定义用于描绘这些3D基因组模型和相关基因组数据的设计空间.

    研究的目的:

    • 系统地研究和分类可视化3D基因组数据的方法.
    • 为3D基因组数据可视化推导一个设计空间.
    • 扩展一个声明式可视化语法 (Gosling),以支持3D基因组数据.

    主要方法:

    • 进行了对300多篇论文的系统调查,可视化3D基因组数据以对视觉表示方法进行分类.
    • 获得了用于3D基因组数据可视化的设计空间,识别了关键属性和模式.
    • 增强了戈斯林可视化语法,以整合对3D基因组数据及其空间特征的支持.

    主要成果:

    • 建立了对3D基因组数据可视化技术的全面调查和分类.
    • 为了可视化3D基因组数据,确定了一个精细的设计空间,并将其定位在现有的分类学中.
    • 增强的戈斯林语法在创建连接3D基因组模型与基因组映射数据的表达性可视化中表现出实用性.

    结论:

    • 该研究为理解和设计3D基因组数据可视化的框架.
    • 增强的戈斯林语法促进了创建复杂的,空间意识的基因组可视化.
    • 开发的工具和框架可用于帮助研究人员探索复杂的3D基因组结构.