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在帕拉食管修复后食管功能:人度和症状结局
Pratik Raichurkar1,2, Oleksandr Khoma3, Fienne Cordeschi4
1Department of Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
概括
高分辨率测量仪 (HRM) 在患有大副食道 (POH) 的患者中是可行的. 手术修复显著改善了诸如消化不良和胃灼热之类的症状,即使食道运动度的变化很小.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 外科手术的结果
背景情况:
- 大型副食道 (POH) 可以引起模仿食道运动障碍的症状.
- 高分辨率测量仪 (HRM) 对于诊断运动问题至关重要,但由于技术挑战,其在巨型POH中的使用是有限的.
- 以前的研究表明,POH患者的HRM失败率很高.
研究的目的:
- 评估HRM在大型POH患者中的可行性和成功率.
- 评估食道运动参数的变化以及POH手术修复前后患者报告的症状.
- 为了与手术后症状改善相关联的测量结果.
主要方法:
- 分析了接受POH修复 (2019-2024) 的患者的潜在数据库.
- 纳入标准:大型POH,手术前和手术后的人力资源管理.
- 主要结果:人力资源管理成功率,人力测量变化. 二级结局:症状得分 (灼热,反,消化不良).
主要成果:
- 在手术前尝试的90.1% (64/71名患者) 中,HRM成功.
- 41名患者完成了手术后的HRM;食管胃节收缩积分 (EGJ-CI) 显著改善 (P=0.018).
- 患者报告的胃烧,吐和消化不良在手术后显著改善 (分别P<0.01,P=0.03,P=0.01).
结论:
- 高分辨率人造测量技术上是可行的在大多数患有大副食道的患者.
- 大型POH的手术修复导致显著的症状缓解和EGJ形态的正常化.
- 经POH修复后的症状改善可能不仅仅取决于食道周平静的可测量变化.
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