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Updated: Jan 8, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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招募ESCRT到单链异构分离体MHCI释放抗原呈现囊泡,可以选择性地刺激T细胞

Blade A Olson1, Kathryn E Huey-Tubman1, Zhiyuan Mao2

  • 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.

Proceedings of the National Academy of Sciences of the United States of America
|December 15, 2025
PubMed
概括

研究人员对非免疫细胞进行了工程设计,以产生表现:MHC复合体的抗原呈现囊泡 (APV). 这些工程APV通过刺激T细胞反应,显示出作为无细胞免疫疗法的潜力.

关键词:
呈现抗原的囊泡.自身免疫性疾病是一种自身免疫性疾病.没有细胞的免疫调节.类主要的组织相容性复合体.

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