维多利祖马布在怀孕期间的安全性:更新的系统审查和全面的元分析
Bachviet Nguyen1, Stephanie Quon1, Astrid-Jane Williams2,3
1Department of Medicine, University of British Columbia, Vancouver, Canada.
Journal of clinical gastroenterology
|December 15, 2025
概括
怀孕期间使用vedolizumab治疗炎症性肠病 (IBD) 并没有与诸如出生缺陷等重大不良结果有关. 然而,人们注意到早产和剖腹产的比率增加,可能是由于疾病的严重程度.
科学领域:
- 胃肠病学和肝病学
- 产科和妇科 产科和妇科
- 药理学和毒理学 药理学和毒理学
背景情况:
- 维多利祖马布是炎症性肠病 (IBD) 的关键先进疗法.
- 它的使用在生殖年龄的个体中正在增加.
- 在怀孕期间评估vedolizumab的安全性对于明智的临床决策至关重要.
研究的目的:
- 在IBD患者怀孕期间系统审查和元分析vedolizumab暴露的安全性.
- 评估与产前使用vedolizumab相关的孕产妇,胎儿和新生儿结局.
- 综合当前关于维多利祖马布对怀孕和婴儿健康的影响的证据.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 搜索了5个数据库,查找怀孕期间的vedolizumab的队列研究和RCT (直到2025年6月26日).
- 分析的结果包括活产,早产,流产,剖腹产,先天性缺陷,SGA和围产并发症.
主要成果:
- 包括8项队列研究 (5项前性,3项后性).
- 维多利祖马布暴露显示早产 (OR=1.33) 和剖腹产 (OR=1.27) 的几率增加.
- 没有发现早期妊娠损失,先天性形,SGA或复合周产并发症的显著关联.
结论:
- 怀孕期间对IBD的vedolizumab暴露与早期妊娠损失,先天性形或复合周产并发症的更高风险无关.
- 增加早产和剖腹产的几率值得考虑,可能与潜在的IBD严重程度有关.
- 这些发现有助于在怀孕期间使用vedolizumab治疗IBD.
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