东南亚成年人中的血液恶性瘤:发病率,死亡率和区域背景
Erin Jay G Feliciano1,2, Urvish Jain3,4, Edward Christopher Dee5
1Department of Medicine, NYC Health + Hospitals/Elmhurst, Icahn School of Medicine at Mount Sinai, Queens, NY.
JCO global oncology
|December 15, 2025
概括
血液性恶性瘤 (HM) 的发病率在东南亚各地各不相同. 富裕国家出现更高的发病率,但较低的死亡率由于更好的医疗保健,而低收入国家面临的诊断障碍和较差的生存结果癌症,如白血病和淋巴瘤.
科学领域:
- 血液瘤学 血液瘤学
- 癌症流行病学 癌症流行病学
- 全球健康差异的差异
背景情况:
- 东南亚 (SEA) 呈现了一个复杂的社会经济多样性和多样化的癌症护理景观.
- 血液性恶性瘤 (HM) 在整个地区构成了重大公共卫生问题.
研究的目的:
- 分析和解释南亚地区主要血液恶性瘤的发病率和死亡率统计数据.
- 突出癌症负担和医疗保健能力的区域差异.
主要方法:
- 利用2022年全球癌症观测站的数据来确定年龄标准化发病率 (ASIR) 和死亡率 (ASMR).
- 专注于非霍奇金淋巴瘤 (NHL),白血病,多发性骨髓瘤 (MM) 和霍奇金淋巴瘤 (HL).
- 使用Segi-Doll世界人口估计的标准化利率,针对20岁及以上的个人.
主要成果:
- 在11个南亚亚洲国家观察到HMs的ASIR和ASMR的区域差异很大.
- 像新加坡这样的国家的发病率较高但死亡率较低表明医疗保健系统强大.
- 在许多南亚国家,较低的发病率和接近发病率的死亡率表明诊断和生存挑战.
结论:
- 报告的高发病率在富裕的东南亚国家可能反映了增强的诊断能力.
- 在低收入国家,类似的发病率和死亡率表明获得及时诊断和治疗的机会有限.
- 死亡率模式揭示了癌症护理基础设施和结果的严重差异,这是由社会经济和系统性不平等驱动的.
相关概念视频
Hematopoiesis
8.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.5K
Prevalence and Incidence
1.5K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.5K
Bone Marrow Sampling and Transplants
816
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
816
Cancer Survival Analysis
629
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
629
Overview of Hematopoiesis
8.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.1K
Regulation of Hematopoietic Stem Cells
3.9K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.9K


