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微环境细胞相互作用对于维持髓纤维化恶性干细胞的功能至关重要

Min Lu1, Md Babu Mia1, Lijuan Xia2

  • 1Icahn School of Medicine at Mount Sinai, New York, New York, United States.

Blood
|December 15, 2025
PubMed
概括

癌症干细胞 (CSCs) 通过与瘤微环境 (TME) 相互作用来驱动癌症. 这项研究模拟了髓纤维化 (MF) 干细胞/TME相互作用,揭示了关键的促炎反应,并维持了恶性克隆的主导地位.

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