胎儿生长限制的时间和严重性 诊断和与围产期发病率的关联
Lilian N Bui1, Sonia Ahluwalia2, Nkechinyelum Q Ogu1
1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
American journal of perinatology
|December 15, 2025
概括
早期或晚期诊断的严重胎儿生长限制 (FGR) 会增加高血压疾病,早产和小于妊娠年龄的风险. 然而,FGR分类显示出预测这些不良妊娠结果的能力很差.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产科 产科 产科 产科 产科
- 新生儿科学 新生儿科学
背景情况:
- 孕产妇胎儿医学协会在2020年更新了胎儿生长限制 (FGR) 诊断标准,根据发病 (早期与晚期) 和严重程度 (轻度与严重程度) 分类.
- 了解这些精细的标准对预测不良妊娠结果的影响对于临床管理至关重要.
研究的目的:
- 评估FGR诊断的时间和严重程度与不良妊娠结果之间的关联.
- 评估不同FGR分类在确定这些结果时的歧视能力.
主要方法:
- 以超声波FGR诊断的单子妊娠的回顾性队列研究 (2020年5月至2021年12月).
- 四个FGR组:早期发作严重,早期发作温和,晚期发作严重和晚期发作温和.
- 用多变量后勤回归和ROC分析来评估关联和预测能力.
主要成果:
- 早期发病的严重FGR与较晚发病的轻度FGR相比,与更高的妊娠高血压疾病,早产和小到妊娠年龄的几率有关.
- 晚期发病的严重FGR也显示出早产和小到妊娠年龄的几率增加.
- 轻度FGR,无论发病时如何,都有相似的不良结果几率,所有FGR分类都显示出预测这些结果的差别能力较差.
结论:
- 早期和晚期严重的FGR都与不良妊娠结果有关,但它们预测这些结果的能力有限.
- 早期发病的严重FGR与妊娠高血压障碍特别相关.
- 严重的FGR,无论时间如何,都会增加早产和怀孕年龄小的风险,尽管在所有分类中,预测准确性仍然很低.
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