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单次过度饮酒对未曾饮酒和暴露饮酒的小鼠模型的影响

Nidal A Qinna¹, Bayan Y Ghanim², Duaa Abuarqoub³

¹Department of Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan; University of Petra Pharmaceutical Center (UPPC), Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|December 15, 2025

概括

过度饮酒暴露会导致严重的肝损伤和新陈代谢中断,无论是酒精原始和依赖的小鼠. 一次过度饮酒会引发氧化应激,改变基因表达,强调过度饮酒的危险性.

科学领域:

毒理学毒理学毒理学
肝病学肝病学是一种肝病学.
代谢学代谢学代谢学

背景情况:

过度饮酒是一种普遍但被低估的公共卫生问题,特别是在年轻人和酒精素朴的人群中.
了解单次暴饮暴饮的急性生理影响对于评估长期健康风险至关重要.

研究的目的:

调查单次狂饮乙醇暴露的血液学,肝脏学,转录学和新陈代谢学后果,在未饮酒和依赖酒精的C57BL/6J小鼠中.
为了比较过度饮酒暴露对以前没有饮酒经验的个体与已确立酒精依赖的人的影响.

主要方法:

在C57BL/6J小鼠中,给予单次狂饮剂量乙醇 (6g/kg).
血液学参数,肝对体重量比,肝脏基因表达 (ADH1,Cat,SOD),肝脏活性氧物种 (ROS) 水平和肝脏组织脂质积累的分析.
综合的代谢分析,以确定代谢途径的变化.

主要成果:

过度饮酒暴露导致先天小鼠的急性肝损伤 (AST升高),依赖性小鼠的血液学参数和肝对体重量比变化.
在两组中都观察到肝脏ADH1,Cat和SOD表达的下调以及肝脏ROS生成的增加,在过度饮食治疗的小鼠中ROS的增加.
乙醇暴露导致了脂质积累,升调的脂原基因和降调的脂肪酸氧化基因,这些影响在以前暴露的动物中加剧. 代谢分析显示了氨基酸和能量代谢的破坏.

结论:

一次过度饮酒暴露会带来重大风险,导致酒精素朴和酒精依赖个体的生理障碍.
过度饮酒会引发肝损伤,氧化压力和代谢失调,强调需要进一步的研究和临床关注,因为它有可能导致严重的长期健康后果.

关键词:

酒精性肝脏是一种酒精性肝脏.酒精主义酒精主义脂肪肝是一种脂肪肝.社交饮料社会饮料

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