癌症治疗中的菌体疗法:机制,新兴创新和转化进展
Chou-Yi Hsu1, Djamila Polatova2, Rania Hameed Hamad3
1Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 717301, Taiwan.
Critical reviews in oncology/hematology
|December 15, 2025
概括
菌体治疗正在通过使用工程菌体作为可编程纳米药物来彻底改变瘤学. 这些菌体向癌症,调节微生物群,激活免疫力,并提供治疗药物,提供精确瘤战略.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 合成生物学 合成生物学
- 纳米医学是一种纳米医学.
背景情况:
- 菌体治疗是瘤学中快速发展的一个领域.
- 菌体是可编程的生物系统,具有超越感染控制的潜力.
- 它们可以根除多抗药性病原体,并调节与瘤相关的微生物群.
研究的目的:
- 探索菌体在癌症治疗中的多方面的应用.
- 为了突出工程菌体构造及其抗瘤功效.
- 讨论AI,CRISPR和合成生物学在精密瘤学的菌体治疗中的整合.
主要方法:
- 选择性消除病原体的菌体的临床前评估 (例如,Fusobacterium nucleatum).
- 开发具有细胞因子 (GM-CSF) 或抗原 (MAGE-A1) 的工程菌体.
- 利用CRISPR-Cas系统进行基因编辑和人工智能设计个性化的菌体尾酒.
主要成果:
- 菌体在口腔和结直肠癌模型中证明了细菌的选择性消除.
- 工程菌体和纳米载体在临床前癌症模型中显示出显著的抗瘤疗效.
- 用CRISPR武装的菌体成功地去除了特定的细菌耐药性基因.
结论:
- 菌体正在演变为用于癌症治疗的多功能平台,集成微生物组调节,免疫激活和基因传递.
- 工程菌体代表了一个有前途的精确瘤学策略,尽管存在诸如免疫清除和监管障碍等挑战.
- 人工智能,CRISPR和合成生物学的融合正在加速菌体治疗的临床可行性.
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