颗粒体中的Fite染色:一个以前未报告的诊断陷和潜在的诊断辅助
Kelly J Butnor1, Rangsinee Nusapan, Alexa Buskey
1Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.
The American journal of surgical pathology
|December 15, 2025
概括
颗粒瘤始终显示Fite染色,模仿感染. 这一发现对于准确诊断至关重要,防止误解颗粒瘤作为传染病原体.
科学领域:
- 病理学 病理学 病理学
- 皮肤病学 皮肤病学
- 历史学 历史学 历史学
背景情况:
- 颗粒瘤在组织学上可能类似于Xanthogranulomatous炎症.
- 在模两可的情况下,组织化学污点通常用于排除感染.
研究的目的:
- 评估已确认的颗粒瘤中Fite染色的频率和模式.
- 调查颗粒瘤中Fite染色的潜在诊断影响.
主要方法:
- 对20例颗粒瘤病例进行了改性酸速 (Fite) 染色.
- 在一些病例中使用了额外的染色 (Ziehl-Neelsen,GMS,B&B) 和mycobacterial IHC.
主要成果:
- 所有20个病例 (100%) 都显示出Fite染色,无论是不整的 (45%) 还是分散的 (55%).
- 囊细胞中的染模仿了细菌形态.
- 在5例中,有4例观察到焦点Ziehl-Neelsen染色;其他染色是负的.
结论:
- 颗粒体始终表现出Fite染色,这种现象可能与聚合物疏水性有关.
- 识别这种Fite染色至关重要,以避免误诊颗粒瘤作为感染.
- 当病史不清楚时,Fite染色可能有助于诊断颗粒瘤.
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