乳腺癌患者的财务毒性:系统性审查和元分析
Juntao Yin1, Chaoyang Wang2, Yantao Hou3
1Department of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, China.
The oncologist
|December 15, 2025
概括
金融毒性 (FT) 在全球范围内显著影响乳腺癌患者. 高收入国家的近40%的患者面临FT,而低收入和中等收入国家的患者比例更高.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 财务毒性 (FT) 描述了医疗保健对患者福祉的不利经济影响.
- 乳腺癌患者经常遇到高昂的自付费用 (OOPC),增加了他们对FT的脆弱性.
研究的目的:
- 评估被诊断患有乳腺癌的个人中金融毒性 (FT) 的患病率.
- 确定特别容易受到乳腺癌治疗经济负担的患者子组.
主要方法:
- 通过PubMed/Medline,Embase,Global Index Medicus,WOS和EBSCO的数据进行了系统的文献审查和元分析,数据截至2025年7月28日.
- 包括专注于乳腺癌患者FT的研究. 使用随机效应模型计算了聚合的FT率,并对不同收入国家 (HIC,LMIC) 的FT流行情况进行了二次分析.
主要成果:
- 分析包括66项研究,共29426名参与者. 高收入国家 (HIC) 的汇总FT率为39.3%,低收入和中等收入国家 (LMIC) 的汇总FT率为72.3%.
- 在包括的研究中,FT的定义中观察到显著的异质性.
结论:
- 金融毒性对乳腺癌患者来说是一个重大的全球挑战.
- 虽然FT率在LMIC中更高,但近40%的HIC患者也经历了这种负担,这表明经济环境之间的差距正在缩小.
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