可以调解心血管--代谢综合征中金属混合物的特定阶段毒性
Wei Zhang1,2, GuangYu Jiang1, Ziyan Liu1
1Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China.
环境金属混合物与心血管--代谢 (CKM) 综合征的进展有关. 被确定为一个关键的毒性驱动因素,具有独特的特定阶段机制,影响CKM发展.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 心血管--代谢 (CKM) 综合征是一个日益增长的全球健康挑战.
- 环境金属混合物对CKM进展的具体影响尚不清楚.
研究的目的:
- 为了研究金属混合物对CKM综合征阶段的综合作用.
- 用先进的统计方法确定CKM的关键毒理学驱动因素.
- 通过不利结果途径 (AOP) 框架阐明金属诱导的CKM的潜在机制.
主要方法:
- 分析了来自1816名参与者的NHANES数据 (2011-2016).
- 应用加权量子总和 (WQS) 回归,通用线性模型 (GLMs),回归和沙普利增量扩展 (SHAP).
- 利用多项式回归和AOP框架来分析金属混合物效应和毒理途径.
主要成果:
- 在混合金属暴露和CKM综合征之间发现了显著的关联 (WQS:β=0.502,p=0.013).
- 在多种回归模型 (WQS,GLM,,SHAP) 中,始终被确定为主要的毒性驱动因素.
- demonstrated a线性剂量-反应关系与CKM综合征.
结论:
- 暴露于金属混合物显著影响CKM综合征的进展.
- AOP框架揭示了CKM中毒性的特定阶段机制.
- 早期CKM阶段与诱导的代谢和免疫失调有关,而晚期阶段涉及平衡,脂质代谢和亡生存平衡的破坏.
更多相关视频
11:04Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
Published on: September 7, 2019
07:52A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
相关概念视频
The Periodic Table and Organismal Elements
Periodic Table Provides Information...
The Periodic Table and Organismal Elements
Chronic Kidney Disease II: Clinical Manifestations
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
