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Updated: Jan 8, 2026

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Slc22a17通过维持海马体内的铁平衡来控制产后神经发生

Lei Tao1, Long Teng1, Mengmeng Ge1,2

  • 1State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.

Nature communications
|December 15, 2025
PubMed
概括

铁转运体SLC22A17对于大脑的铁平衡和产后神经生成至关重要. 它的损失导致氧化应激,神经干细胞死亡和认知缺陷,这表明它是神经疾病的治疗目标.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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