在波利尼西亚扩张期间,BMI上的多基因和单位选择
Hanako Miwa1, Mariko Isshiki1,2, Izumi Naka1
1Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Journal of human genetics
|December 15, 2025
概括
这种CREBRF基因变异在通加人中表现出强烈的阳性选择,这与波利尼西亚航行期间高效储存能源有关. 最近的选择转变可能有利于较低的BMI,这表明进化不匹配现代环境.
科学领域:
- 人类进化遗传学人类进化遗传学
- 人口遗传学 人口遗传学
- 代谢性疾病研究研究.
背景情况:
- "节约性"变体假设表明,储能的遗传适应有助于现代肥胖.
- 了解这些变异对身体质量指数 (BMI) 的时间和人口特异性影响至关重要.
研究的目的:
- 调查CREBRF rs373863828-A变种在通加人群中的进化史和影响.
- 探索多基因适应在BMI随时间变化的作用,在祖先的通加人.
主要方法:
- 22名通加人的全基因组测序.
- 使用CLUES程序分析等位基频率轨迹.
- 检查多基因选择信号使用两极化特征集成的哈普洛型得分.
主要成果:
- 在Tongans中复制了CREBRF rs373863828-A变体的阳性选择信号,表明波利尼西亚更广泛的适应压力.
- 在过去的100代里,rs373863828-A等位基因频率显著增加,与波利尼西亚海上扩张相吻合.
- 观察到BMI多基因分数的初始增加,随后最近的下降,有证据表明选择有利于最近几代人更低的BMI.
结论:
- 在海洋扩散期间,CREBRF变异被强烈选择,帮助适应食物有限的环境.
- 多种适度效果的变体也为长途航行中的适应做出了贡献.
- 最近的选择压力可能正在向较低的BMI转移,突出显示了与现代环境的潜在进化不匹配.
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