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Updated: Jan 8, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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通过PKD1对CBX8的酸化抑制了PRC1的活性,并促进了细胞衰老

Zhiqiang Fang1, Doudou Liu1,2, Yuanyuan Su1,3

  • 1Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Integration of Chinese and Western Medicine, School of Basic Medical Science, Peking University, Beijing, 100191, China.

Oncogene
|December 15, 2025
PubMed
概括

蛋白激酶D1 (PKD1) 酸化染色体8 (CBX8),这是一个关键的表观遗传调节器. 这种酸化会影响CBX8的稳定性和Polycomb抑制复合体1 (PRC1) 的功能,最终影响细胞衰老.

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