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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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阿帕提尼布诱导的STAT1/NK轴激活增加了PD-1抑制剂在晚期肝细胞癌中的有效性

Lin-Sheng Cui1, Meng-Ru Wei1, Jun Fu1

  • 1Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China.

Scientific reports
|December 15, 2025
PubMed
概括

与阿帕蒂尼布和PD-1抑制剂的联合治疗通过激活STAT1/NK细胞轴和重塑瘤微环境,在晚期肝细胞癌 (HCC) 中显示出增强的疗效.

关键词:
抗PD-1疗法是一种治疗.阿帕提尼布 (Apatinib) 是一种药物.肝细胞癌是肝细胞癌.在STAT1/NK轴上

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