在非性消化不良和胃患者中比较胃微生物群概况
Silva Polat Sari1, Aliye Soylu2, Kivanc Derya Peker3
1Vocational School of Health Services, Istanbul Aydin University, Istanbul, 34295, Turkey.
BMC microbiology
|December 15, 2025
概括
在胃肠道疾病中缺乏Helicobacter pylori (H. pylori) 与口腔细菌如Alloprevotella,Porphyromonas和Neisseria的增加有关. 这项研究为土耳其患者的胃微生物生态提供了新的见解.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类健康 人类健康 人类健康
背景情况:
- 人的胃内有着多样化的微生物群,不仅仅是Helicobacter pylori (H. pylori).
- 当H. pylori缺席时,口腔细菌可能会主导胃,但它们在胃肠疾病中的作用尚不清楚.
- 了解胃微生物的变化对于诊断和治疗胃疾病至关重要.
研究的目的:
- 分析和比较土耳其患者的胃微生物组合,非性消化不良 (NUD) 和胃病 (PUD).
- 调查这些患者群体中H. pylori状态和胃微生物特征之间的关联.
- 阐明口腔来源细菌在H. pylori阴性胃肠疾病中的作用.
主要方法:
- 98名患者进行了内镜评估,并分为NUD (n=52) 和PUD (n=46) 组.
- 胃活检样本使用定量实时PCR (qPCR) 分析了H. pylori的相对丰度.
- 下一代测序被用于全面的胃微生物群概况.
主要成果:
- 在71.4%的样本中检测到H. pylori DNA,PUD (82.6%) 的患病率高于NUD (61.5%) 的患者 (p=0.02).
- 阴性H. pylori的NUD患者表现出更高的Alloprevotella丰度 (p<0.05).
- 与H. pylori阴性NUD患者相比,H. pylori阴性PUD患者的Porphyromonas和Neisseria增加 (p<0.05),这表明口腔细菌的机会性扩张.
结论:
- 在胃部疾病中缺少H. pylori与微生物群组成的显著转变有关.
- 口腔来源的细菌 (Alloprevotella,Porphyromonas,Neisseria) 增加了H. pylori阴性胃肠疾病的发生.
- 这项研究为NUD和PUD的土耳其患者的胃微生物生态提供了新的区域洞察力.
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