一个尿路微RNA衰老时钟准确地预测了生物年龄
Milos Havelka1, Atsushi Satomura1,2, Hiroki Yamaguchi1
1Craif Inc., Nagoya, Japan.
npj aging
|December 15, 2025
概括
研究人员开发了一种新的尿路microRNA (miRNA) 衰老时钟. 这种非侵入性生物标志物准确地预测了生物年龄,超过了基于血液的时钟.
科学领域:
- 生物遗传学 生物遗传学
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 衰老是一个复杂的过程,对健康有重大影响.
- 对于衰老的非侵入性生物标志物非常受欢迎.
- 尿液为可扩展的生物标志物开发提供了一个有希望的来源.
研究的目的:
- 开发和验证一个基于尿路microRNA (miRNA) 的衰老时钟.
- 确定尿液作为衰老生物标志物的可行,非侵入性来源.
- 为了确定与生物年龄相关的关键尿路miRNAs.
主要方法:
- 机器学习算法应用于6331名成年人的尿液miRNA表达数据.
- 一个预测生物年龄模型被训练并独立验证.
- 确定了关键的miRNA生物标志物,包括已知的geromiRs.
主要成果:
- 尿 miRNA 衰老时钟在验证时获得了大约 4.4 年的平均绝对误差 (MAE) 和大约 0.79 的 R2.
- 时钟确定了特定的miRNAs,如miR-34a-5p,miR-31-5p,miR-146a-5p和miR-155-5p作为关键的衰老生物标志物.
- 虽然比DNA甲基化时钟的精度略低,但尿路miRNA时钟在性能方面超过了基于血液的miRNA和mRNA时钟.
结论:
- 尿路miRNAs代表了一个有希望的,真正的非侵入性生物标志物来评估生物年龄.
- 这种新型的衰老时钟在预测与年龄相关的疾病风险方面具有潜在的应用.
- 尿液分析为监测衰老生物标志物提供了一个可扩展和可访问的方法.
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