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Updated: Jan 8, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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广泛的CRISPR相关环核酶Crn4的结构和机制

Haotian Chi1, Ville Hoikkala1, Stephen McMahon1

  • 1School of Biology, University of St Andrews, BMS building, North Haugh, St Andrews, Fife, UK.

Nature communications
|December 15, 2025
PubMed
概括

研究人员发现了Crn4,这是一种新型环核酶,对III型CRISPR免疫力至关重要. 这种酶降解循环基酸信号,重置抗病毒防御系统,并揭示了用于循环核酸识别的新蛋白质折叠.

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