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感官运动功能作为认知衰退的早期标志物和阿尔茨海默病的生物标志物负担

Semere Bekena¹, Ramkrishna K Singh², Yiqi Zhu²

¹Department of Neurology, Washington University School of Medicine, 600 S. Taylor Avenue, Suite 111Z, St. Louis, MO, 63110, USA. b.semere@wustl.edu.

|December 16, 2025

概括

简单的物理测试,如步行速度和反应时间,可以在老年人中预示早期的认知衰退. 这些感觉运动措施有助于识别有风险的个体,以帮助预防痴呆的努力.

科学领域:

神经科学是一个神经科学.
老年学是一门学科.
生物标志物生物标志物

背景情况:

在认知正常的老年人中早期发现认知衰退标志物对于预防痴呆症至关重要.
感官运动测量 (步行速度,握力,反应时间) 可能表明当前和未来的认知障碍.

研究的目的:

检查基线感觉运动功能和认知衰退在认知正常的老年人之间的关联.
调查传感运动测量作为临床前阿尔茨海默病的潜在早期指标.

主要方法:

对246位认知正常的老年人进行前性队列研究.
基线评估包括握力,步行速度,反应时间和临床前阿尔茨海默氏症认知复合物 (PACC).
随访时间平均为4年,对人口统计和APOE ε4状态进行了调整. 横截面分析包括CSF和血生物标志物 (粉样蛋白,,NfL).

主要成果:

较慢的步行速度与更高的CSF tau/Aβ42和血NfL水平相关.
较慢的反应时间与较低的基线PACC得分有关.
较低的握力和缓慢的步行速度预测了纵向较低的认知表现;缓慢的步行速度预测了更快的下降.

结论:

感官运动功能的测量与当前和未来的认知表现有关.
这些措施支持感官运动评估在早期识别有认知能力下降风险的老年人中的作用.
步行速度和反应时间显示出作为痴呆风险查的可访问工具的承诺.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.认知能力下降认知能力下降步行速度步行速度握力强度握力强度握力强度身体的脆弱性身体的脆弱性反应时间反应时间

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