饮食中的黄素,特别是阿皮基宁和黄素与表型衰老加速的关联:使用NHANES数据的横截面研究
Xiaoqiao Wang1, Chang Liu, Guixia Li
1Department of Nephrology, Shenzhen Third People's Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Medicine
|December 16, 2025
概括
饮食中摄入较高的类黄素,如阿皮基宁和白素,与缓慢的生物衰老有关. 这表明黄可能通过其抗炎和抗氧化作用促进健康的衰老.
科学领域:
- 营养流行病学 营养流行病学
- 生物遗传学 生物遗传学
- 分子营养分子营养学
背景情况:
- 类黄,如阿皮基宁和黄素,具有与衰老相关的已知的抗炎和抗氧化特性.
- 目前,将弗拉消费与表型衰老加速 (PhenoAgeAccel) 联系起来的流行病学数据有限.
研究的目的:
- 为了研究饮食中的黄摄入量与PhenoAgeAccel在美国成年人群中存在的关联,在一个庞大的,具有全国代表性的美国成年人群中.
- 探索与PhenoAgeAccel相关的阿皮基宁和白素的特定作用.
主要方法:
- 来自国家健康和营养检查调查 (2007-2010年和2017-2018年) 的10,789名美国成年人的数据分析.
- PhenoAgeAccel计算为从回归的表型年龄到时间年龄的剩余值.
- 通过24小时回忆评估饮食摄入量;统计分析包括加权多变量逻辑回归和受限立方线.
主要成果:
- 较高的总黄摄入量显示PhenoAgeAccel的剂量依赖性显著下降 (P趋势<.001).
- 增加的弗拉摄入量与PhenoAgeAccel的几率降低有关,与阿皮根因和黄素的类似反向关联有关.
- 对于所有黄素,观察到显著的非线性剂量反应关系,在人口统计和健康亚组中发现一致的结果.
结论:
- 饮食中较高的黄摄入量,特别是阿皮基宁和黄素,与美国成年人的PhenoAgeAccel降低密切相关.
- 这些发现强调了黄作为可修改的饮食因素的潜力,有助于健康的衰老.
- 进一步的研究可以探索这些关联及其临床影响背后的机制.
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