一名因地幔细胞淋巴瘤而接受奥雷拉布鲁替尼治疗的患者的多重皮肤瘤:病例报告
Xuefeng Fu1,2, Yuxi Zhang1,2, Lei Zeng1,2
1Department of Dermatology, Jinhua Municipal Central Hospital Medical Group, Jinhua, Zhejiang Province, China.
Medicine
|December 16, 2025
概括
长期使用布鲁顿氨酸激酶抑制剂 (BTKi) 治疗上衣细胞淋巴瘤 (MCL) 可能会增加皮肤癌的风险. 一名接受Orelabrutinib治疗的患者患有多种皮肤瘤,突出显示在BTKi治疗期间需要定期进行皮肤学监测.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 膜细胞淋巴瘤 (MCL) 是一种具有攻击性的B细胞非霍奇金淋巴瘤.
- 布鲁顿氨酸激酶抑制剂 (BTKi) 改善MCL预后,但可以导致免疫抑制和二次恶性瘤,包括皮肤癌与第一代药物如Ibrutinib.
研究的目的:
- 报告一个患有MCL的患者出现多种皮肤瘤的病例,该患者接受了下一代布鲁顿氨酸激酶抑制剂 (BTKi) 治疗,Orelabrutinib.
- 调查奥雷拉布鲁替尼与二次性皮肤恶性瘤之间的潜在关联.
主要方法:
- 一个病例报告,是一名77岁的MCL男性患者接受了Orelabrutinib (150mg/天).
- 皮肤瘤进行了病理检查,证实了基底细胞癌,状细胞癌,行为性角质瘤和斑疹性角质瘤.
- 终止了奥雷拉布鲁替尼的治疗,患者接受了化疗. 进行了皮肤瘤的手术切除和重建.
主要成果:
- 患者在Orelabrutinib治疗期间发展出多种不同的皮肤瘤.
- 对皮肤瘤的手术干预导致了良好的伤口恢复.
- 该患者最终死于肺部感染和多器官衰竭,手术后5个月.
结论:
- 奥雷拉布鲁丁尼可能与多种皮肤瘤的发展有关,可能是由于免疫调节失调.
- 对于接受长期BTKi治疗的患者,建议定期进行皮肤学检查,以监测二级恶性瘤.
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