估计血体积状态与慢性病之间的关联:一个横截面研究
Xuyang Luo1,2, Fei Deng1,2
1Department of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Medicine
|December 16, 2025
概括
估计的血体积 (ePVS) 与慢性病 (CKD) 患病率和慢性病患者的死亡风险有关. 提升ePVS的早期检测可能会改善预后,并减缓CKD的进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 影响全球数百万人,患病率和死亡率很高.
- 血体积状态越来越被认为是CKD管理的关键因素.
- 估计血体积状态 (ePVS) 和CKD结果之间的关系需要进一步阐明.
研究的目的:
- 调查ePVS和CKD流行率之间的关联.
- 评估ePVS对CKD患者全因和心血管疾病 (CVD) 死亡率的影响.
- 确定与CKD风险增加相关的ePVS的潜在值.
主要方法:
- 对来自NHANES 1999-2018年龄组的25142名参与者的分析.
- 使用二进制后勤回归,考克斯比例危险模型和受限立方线 (RCS).
- 进行了值和接收器运行特征 (ROC) 曲线分析,以评估ePVS的预测能力.
主要成果:
- 权衡的CKD患病率为18.04%.
- 观察到ePVS和CKD患病率之间的非线性相关性,高ePVS (>3.198) 与CKD风险增加有关.
- ePVS在CKD预测方面表现出适度的歧视,并且与CKD患者的CKD发生率和死亡率有关.
结论:
- ePVS与CKD患病率和死亡率有关,包括心血管疾病死亡率.
- 升高的ePVS水平与增加的CKD风险和患病率相关.
- 早期监测和干预慢性脏病患者的EPVS升高可能会改善结果并减缓疾病的进展.
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