一种复发性/耐药性急性先导细胞白血病在用venetoclax进行化疗后实现完全反应
Xiaolin Zhang1, Shuhong Hao, Chunmei Hu
1Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Medicine
|December 16, 2025
概括
这项案例研究表明,患有复发性急性肌肉细胞白血病 (APL) 的患者通过使用venetoclax (VEN) 结合化疗实现了完全反应. 这种基于VEN的向治疗为耐火APL病例提供了有前途的治疗选择.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 急性促细胞白血病 (APL) 通常对全转录氨酸 (ATRA) 和环素化疗反应良好.
- 复发性或耐火性APL具有重大治疗挑战,特别是在患有DNMT3A突变等不良预后标志物的患者中.
- 标准治疗可能会在一些APL患者中失败,需要新的治疗方法.
研究的目的:
- 报告患有多次复发和耐火性急性肌肉细胞白血病的患者的成功治疗结果.
- 评估venetoclax (VEN) 与伊达鲁比辛和细胞氨酸结合的疗效,作为APL的救援化疗.
- 突出针对性治疗与化疗结合用于挑战性APL病例的潜在潜力.
主要方法:
- 一名58岁的男性患者有20年的APL病史,出现了复发性疾病和全细胞减小.
- 该患者被诊断为复发性/耐药性APL,由DNMT3A突变和复杂的型复杂化.
- 进行了救援化疗,包括venetoclax (VEN),idarubicin和cytarabine.
主要成果:
- 患者在完成基于VEN的救援化疗方案后实现了完整的反应.
- 治疗后的评估显示没有残留的白血病症状.
- 组合疗法在这个具有挑战性的APL病例中显示出显著的疗效.
结论:
- 与化疗相结合的Venetoclax (VEN) 是复发性和耐药APL的一种有希望的治疗策略.
- 监测耐药基因对于管理复发性/耐药APL至关重要.
- 这一案例强调了向疗法在克服APL治疗耐药性的潜力.
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