尽管有类似的疾病活动,但炎症性肠病的男性占主导地位:一项大型回顾性队列研究
Ali Atay1, Mucahit Ergul1, Oguz Ozturk1
1Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara, Turkey.
Medicine
|December 16, 2025
概括
虽然男性更常被诊断为炎症性肠病 (IBD),但与性别相关的预后差异很小. 然而,女性患者经历更多的肠外表现,这表明需要基于性别的管理策略.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎和克罗恩病 (CD),表现出显著的临床异质性.
- 新出现的证据表明,与性别相关的差异可能会影响IBD的过程和预后.
研究的目的:
- 为了研究性别对炎症性肠病 (IBD) 预后的影响,在一个大患者队列中.
- 分析疾病发病,活动,肠外表现 (EIMs),治疗和手术结果的基于性别的变化.
主要方法:
- 从1993年7月至2025年4月期间诊断的1774名IBD患者的人口,临床和治疗数据的回顾性分析.
- 男性和女性患者之间的疾病特征和结果的比较,包括疾病活性指数和住院和手术率.
主要成果:
- 在IBD患病率中观察到男性占主导地位 (61%),在性结肠炎和CD中男性对女性的比例更高.
- 女性患者呈现出较早发病的IBD和更高频率的EIM,特别是外周关节炎和结节性红斑.
- 在疾病严重程度,住院或治疗升级方面没有发现显著的性别差异,尽管女性CD患者的基线疾病活性较高.
结论:
- 尽管在男性中患病率更高,但IBD预后在疾病活动,治疗升级和手术需求方面,与性别相关的差异很小.
- 患有IBD的女性患者表现出更大的EIM负担,这凸显了临床管理中性别特定考虑的重要性.
- 基于性别的方法对于优化炎症性肠道疾病的临床管理至关重要.
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